Periodontitis : From Dysbiotic Microbial Immune Response to Systemic Inflammation

Periodontitis : From Dysbiotic Microbial Immune Response to Systemic Inflammation

Periodontology

Periodontitis is an infection-induced inflammatory disease accounting for huge healthcare costs and socio-economic impacts. Bacteria from the indigenous oral flora colonize the interspace between the tooth and the connective tissue, which induces an inflammatory response. If the bacteria proliferate and release virulence factors, they cause an imbalance in the host inflammatory response that induces degenerative processes in the surrounding tissues. This process is often slow, and the disease affects mainly older people, but the process could be rapid and affect young individuals if certain pathogens colonize the area. The two most studied periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, express virulence factors, including proteases and exotoxins. Periodontal bacteria and their products can be translocated to the peripheral circulation and are therefore linked to the risk pattern of several systemic diseases. However, it is not known if the increased risk for systemic disease associated with periodontitis is an effect of the invading bacteria and/or their released products, the release of components from the local inflammatory response, or a common host susceptibility pattern. The most studied periodontitis-associated systemic diseases are cardiovascular diseases and rheumatoid arthritis. Here, we want to shed light on mechanisms behind the associations of periodontal infections with systemic inflammation.

Johansson, Anders (editor)

https://directory.doabooks.org/handle/20.500.12854/69297

MDPI - Multidisciplinary Digital Publishing Institute

Basel, Switzerland, 2020

Sulistiorini

https://creativecommons.org/licenses/by/4.0/

1. Jan Oscarsson and Anders Johansson
Comment from the Editor to the Special Issue: “Periodontitis: From Dysbiotic Microbial
Immune Response to Systemic Inflammation”
2. Nagihan Bostanci, Toshiharu Abe, Georgios N. Belibasakis and George Hajishengallis
TREM-1 Is Upregulated in Experimental Periodontitis, and Its Blockade Inhibits IL-17A and
RANKL Expression and Suppresses Bone Loss
3. Milla Pieti¨ainen, John M. Liljestrand, Ramin Akhi, K˚are Buhlin, Anders Johansson,
Susanna Paju, Aino Salminen, P¨aivi M¨antyl¨a, Juha Sinisalo, Leo Tj¨aderhane, Sohvi H¨orkk¨o
and Pirkko J. Pussinen
Saliva and Serum Immune Responses in Apical Periodontitis
4. Gunnar Dahlen, Amina Basic and Johan Bylund
Importance of Virulence Factors for the Persistence of Oral Bacteria in the Inflamed Gingival
Crevice and in the Pathogenesis of Periodontal Disease
5. Eduardo G´omez-Ba˜ nuelos, Amarshi Mukherjee, Erika Darrah and Felipe Andrade
Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and
Aggregatibacter actinomycetemcomitans

Pdf

English

Textbooks

DOI
10.3390/books978-3-03943-508-1

ISBN
9783039435074, 9783039435081