Metastatic Progression and Tumour Heterogeneity

Metastatic Progression and Tumour Heterogeneity

Tumor

Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.

Hollande, Fred (editor)

Merino, Delphine (editor)

https://directory.doabooks.org/handle/20.500.12854/68966

MDPI - Multidisciplinary Digital Publishing Institute

2020

Dewi Puspitasari

https://creativecommons.org/licenses/by/4.0/

Zhu, T.S.; Costello, M.A.; Talsma, C.E.; Flack, C.G.; Crowley, J.G.; Hamm, L.L.; He, X.; Hervey-Jumper, S.L.;
Heth, J.A.; Muraszko, K.M.; et al. Endothelial cells create a stem cell niche in glioblastoma by providing
NOTCH ligands that nurture self-renewal of cancer stem-like cells. Cancer Res. 2011, 71, 6061–6072.

Pdf

English

Textbooks

DOI
10.5772/intechopen.95174

ISBN
9781839697470, 9781839697463, 9781839697487

Basel