Advances in Mucoadhesive Polymers and Formulations for Transmucosal Drug Delivery

Advances in Mucoadhesive Polymers and Formulations for Transmucosal Drug Delivery

Polymers
Pharmacy

Mucoadhesion, defined as the ability of materials to stick to mucosal tissues in the human body, has attracted substantial interest of researchers over the past few decades. The applicability of mucoadhesion in the drug delivery has been first demonstrated in 1947 but received wide recognition only in the early 1980 th. Currently there are several routes of administration established for transmucosal drug delivery, where mucoadhesive materials increasingly find some applications. These include ocular, nasal, oromucosal, gastrointestinal, esophageal, vaginal, rectal and intravesical drug delivery. Each route will have some specific physiological features that will determine the possibility of drug administration and the design of suitable dosage forms. Mucoadhesive dosage forms have been formulated as tablets, lozenges, wafers, pessaries, films, gels, liquid and semi-solid systems as well as suspensions of various nano- and microparticles. Hydrophilic polymers have been shown to exhibit mucoadhesive properties due to specific interactions with mucins as well as because of their ability to form viscous solutions and penetration into mucus gel. There is currently a continuously increased interest in the design of novel mucoadhesive materials and dosage forms. These dosage forms could be formulated using conventional hydrophilic polymers, their combinations and complexes. Additionally there is currently a strong interest of researchers in chemical modification of existing polymers to enhance their mucoadhesive properties. This book represents a collection of reviews and original research papers, focusing on mucoadhesive polymers and formulations for transmucosal drug delivery. It includes some contributions reporting the design of nanoparticles, gels, tablets, films, beads, and nanofibrous systems. Additionally some of the contributions describe methodologies for chemical modification of chitosan and hyaluronic acid to enhance their mucoadhesive properties.

Vitaliy V. Khutoryanskiy (Ed.)

https://www.mdpi.com/journal/polymers/special_issues/Advances_in Mucoadhesive Polymers and Formulations for Transmucosal Drug Delivery

MDPI
St. Alban-Anlage 66
4052 Basel, Switzerland

2020

Vitaliy V. Khutoryanskiy
J®F

CC BY-NC-ND.

Pdf

English

Textbooks

ISBN 978-3-03928-752-9 (Pbk)
ISBN 978-3-03928-753-6 (PDF)