New Mechanisms of Action of Natural Antioxidants in Health and Disease

New Mechanisms of Action of Natural Antioxidants in Health and Disease

Antioxidants

The current understanding of the complex role of ROS in the organism, and pathological sequelae of oxidative stress, points to the necessity of comprehensive studies of antioxidant reactivities and interactions with cellular constituents. Many of the protective actions of natural antioxidants in health and diseases have been ascribed to their antioxidant properties, but in recent years, many studies have suggested that their classic hydrogen-donating antioxidant activity is unlikely to be the sole explanation for their effects. First of all, natural antioxidants are broadly metabolized in vivo, resulting in significant modifications. Moreover, the concentrations of natural antioxidants and their metabolites in vivo are lower than those usually utilized in vitro. Consequently, natural antioxidants do not exert their biological action in vivo viasimply reacting with ROS. Accumulating evidence suggests that the cellular effects of natural antioxidants may be mediated by their interactions with specific proteins that are central to intra cellular signaling cascades, modulating the expression and activity of key proteins, influencing epigenetic mechanisms, or modulating gut microbiota.

SilvanaHrelia (Ed.)
CristinaAngeloni (Ed.)

https://www .mdpi.com/journal/
antioxidants/special_issues/natural_antioxidants

MDPI
St. Alban-Anlage 66
4052 Basel, Switzerland

2020

SilvanaHrelia
CristinaAngeloni
J®F

CC BY-NC-ND

Pdf

English

Textbooks

ISBN978-3-03936-268-4(Pbk)
ISBN978-3-03936-269-1(PDF)