AR Signaling in Human Malignancies: Prostate Cancer and Beyond

AR Signaling in Human Malignancies: Prostate Cancer and Beyond

Cancer

The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This Special Issue of Cancers initially reviews the role of AR in advanced prostate cancer, and then explores the potential importance of AR signaling in other epithelial malignancies. The first few articles focus on the use of novel AR-targeting therapies in castration-resistant prostate cancer and the mechanisms of resistance to novel antiandrogens, and they also outline the interaction between AR and other cellular pathways, including PI3 kinase signaling, transcriptional regulation, angiogenesis, stromal factors, Wnt signaling, and epigenetic regulation in prostate cancer. The next several articles review the possible role of androgens and AR signaling in breast cancer, bladder cancer, salivary gland cancer, and hepatocellular carcinoma, as well as the potential treatment implications of using antiandrogen therapies in these non-prostatic malignancies.

Emmanuel S. Antonarakis (Ed.)

https://directory.doabooks.org/handle/20.500.12854/41149

www.mdpi.com/books

2018

Dewi Puspitasari

2018

Abd El-Rehim, D.M.; Ball, G.; Pinder, S.E.; Rakha, E.; Paish, C.; Robertson, J.F.; Macmillan, D.; Blamey, R.W.;
Ellis, I.O. High-throughput protein expression analysis using tissue microarray technology of a large
well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA
expression analyses. Int. J. Cancer 2005, 116, 340–350. [CrossRef] [PubMed]

Pdf

English

Textbooks

DOI
10.3390/books978-3-03842-739-1

Basel