Drug—Drug Interactions

DrugDrug_Interactions cov.jpg

Dublin Core

Title

Drug—Drug Interactions

Subject

Pharmaceutics

Description

Drug–drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug efficacy or increased toxicity of the affected drug. Some well-known interactions are known to be the cause of adverse drug reactions (ADRs) that are life threatening to the patient. Traditionally, DDI have been evaluated around the selective action of drugs on specific CYP enzymes. The interaction of drugs with CYP remains very important in drug interactions but, recently, other important mechanisms have also been studied as contributing to drug interaction including transport- or UDP-glucuronyltransferase as a Phase II reaction-mediated DDI. In addition, novel mechanisms of regulating DDIs can also be suggested. In the case of the substance targeted for interaction, not only the DDIs but also the herb–drug or food–drug interactions have been reported to be clinically relevant in terms of adverse side effects. Reporting examples of drug interactions on a marketed drug or studies on new mechanisms will be very helpful for preventing the side effects of the patient taking these drugs. This Special Issue aims to highlight current progress in understanding both the clinical and nonclinical interactions of commercial drugs and the elucidation of the mechanisms of drug interactions.

Creator

Dong Hyun Kim Sangkyu Lee

Source

mdpi.com/books/pdfview/book/4341

Publisher

MDPI AG St. Alban-Anlage 66 4052 Basel, Switzerland Tel: +41 61 683 77 34 www.mdpi.com/books books@mdpi.com

Date

September 2021

Contributor

J®F

Rights

CC BY-NC-ND

Format

Pdf

Language

English

Type

Textbook

Identifier

ISBN 978-3-0365-2035-3 (Hbk) ISBN 978-3-0365-2036-0 (PDF)

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