Dublin Core
Title
Drug—Drug Interactions
Subject
Pharmaceutics
Description
Drug–drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug
efficacy or increased toxicity of the affected drug. Some well-known interactions are
known to be the cause of adverse drug reactions (ADRs) that are life threatening to the
patient. Traditionally, DDI have been evaluated around the selective action of drugs on
specific CYP enzymes. The interaction of drugs with CYP remains very important in drug
interactions but, recently, other important mechanisms have also been studied as
contributing to drug interaction including transport- or UDP-glucuronyltransferase as a
Phase II reaction-mediated DDI. In addition, novel mechanisms of regulating DDIs can
also be suggested. In the case of the substance targeted for interaction, not only the DDIs
but also the herb–drug or food–drug interactions have been reported to be clinically
relevant in terms of adverse side effects. Reporting examples of drug interactions on a
marketed drug or studies on new mechanisms will be very helpful for preventing the side
effects of the patient taking these drugs. This Special Issue aims to highlight current
progress in understanding both the clinical and nonclinical interactions of commercial
drugs and the elucidation of the mechanisms of drug interactions.
Creator
Dong Hyun Kim
Sangkyu Lee
Source
mdpi.com/books/pdfview/book/4341
Publisher
MDPI AG
St. Alban-Anlage 66
4052 Basel, Switzerland
Tel: +41 61 683 77 34
www.mdpi.com/books
books@mdpi.com
Date
September 2021
Contributor
J®F
Rights
CC BY-NC-ND
Format
Pdf
Language
English
Type
Textbook
Identifier
ISBN 978-3-0365-2035-3 (Hbk)
ISBN 978-3-0365-2036-0 (PDF)