Dublin Core
Title
Features of Pathogenesis of Human Viral Infections and Antiviral Drugs
Subject
Pathogenesis
Infections
Antiviral Drugs
Drugs
Medicina
inflammation
Infections
Antiviral Drugs
Drugs
Medicina
inflammation
Description
Warts are the most common lesions caused by human
papillomavirus (HPV). Recent research suggests that oxidative stress and inflammation are involved
in the pathogenesis of HPV-related lesions. It has been shown that the soluble receptor for advanced
glycation end products (sRAGE) may act as a protective factor against the deleterious effects of
inflammation and oxidative stress, two interconnected processes. However, in HPV infection, the role
of sRAGE, constitutively expressed in the skin, has not been investigated in previous studies. Materials
and Methods: In order to analyze the role of sRAGE in warts, we investigated the link between
sRAGE and the inflammatory response on one hand, and the relationship between sRAGE and the
total oxidant/antioxidant status (TOS/TAS) on the other hand, in both patients with palmoplantar
warts (n = 24) and healthy subjects as controls (n = 28). Results: Compared to the control group,
our results showed that patients with warts had lower levels of sRAGE (1036.50 ± 207.60 pg/mL
vs. 1215.32 ± 266.12 pg/mL, p < 0.05), higher serum levels of TOS (3.17 ± 0.27 vs. 2.93 ± 0.22 μmol
H2O2 Eq/L, p < 0.01), lower serum levels of TAS (1.85 ± 0.12 vs. 2.03 ± 0.14 μmol Trolox Eq/L, p < 0.01)
and minor variations of the inflammation parameters (high sensitivity-CRP, interleukin-6, fibrinogen,
and erythrocyte sedimentation rate). Moreover, in patients with warts, sRAGE positively correlated
with TAS (r = 0.43, p < 0.05), negatively correlated with TOS (r = −0.90, p < 0.01), and there was no
significant correlation with inflammation parameters. There were no significant differences regarding
the studied parameters between groups when we stratified the patients according to the number of
the lesions and disease duration. Conclusions: Our results suggest that sRAGE acts as a negative
regulator of oxidative stress and could represent a mediator involved in the development of warts.
However, we consider that the level of sRAGE cannot be used as a biomarker for the severity of warts.
To the best of our knowledge, this is the first study to demonstrate that sRAGE could be involved in
HPV pathogenesis and represent a marker of oxidative stress in patients with warts.
papillomavirus (HPV). Recent research suggests that oxidative stress and inflammation are involved
in the pathogenesis of HPV-related lesions. It has been shown that the soluble receptor for advanced
glycation end products (sRAGE) may act as a protective factor against the deleterious effects of
inflammation and oxidative stress, two interconnected processes. However, in HPV infection, the role
of sRAGE, constitutively expressed in the skin, has not been investigated in previous studies. Materials
and Methods: In order to analyze the role of sRAGE in warts, we investigated the link between
sRAGE and the inflammatory response on one hand, and the relationship between sRAGE and the
total oxidant/antioxidant status (TOS/TAS) on the other hand, in both patients with palmoplantar
warts (n = 24) and healthy subjects as controls (n = 28). Results: Compared to the control group,
our results showed that patients with warts had lower levels of sRAGE (1036.50 ± 207.60 pg/mL
vs. 1215.32 ± 266.12 pg/mL, p < 0.05), higher serum levels of TOS (3.17 ± 0.27 vs. 2.93 ± 0.22 μmol
H2O2 Eq/L, p < 0.01), lower serum levels of TAS (1.85 ± 0.12 vs. 2.03 ± 0.14 μmol Trolox Eq/L, p < 0.01)
and minor variations of the inflammation parameters (high sensitivity-CRP, interleukin-6, fibrinogen,
and erythrocyte sedimentation rate). Moreover, in patients with warts, sRAGE positively correlated
with TAS (r = 0.43, p < 0.05), negatively correlated with TOS (r = −0.90, p < 0.01), and there was no
significant correlation with inflammation parameters. There were no significant differences regarding
the studied parameters between groups when we stratified the patients according to the number of
the lesions and disease duration. Conclusions: Our results suggest that sRAGE acts as a negative
regulator of oxidative stress and could represent a mediator involved in the development of warts.
However, we consider that the level of sRAGE cannot be used as a biomarker for the severity of warts.
To the best of our knowledge, this is the first study to demonstrate that sRAGE could be involved in
HPV pathogenesis and represent a marker of oxidative stress in patients with warts.
Creator
Stefano Aquaro (Ed.)
Source
https://www.mdpi.com/journal/medicina/special issues/human_viral infections
Publisher
MDPI
St. Alban-Anlage 66
4052 Basel, Switzerland
St. Alban-Anlage 66
4052 Basel, Switzerland
Date
2020
Contributor
Stefano Aquaro
J®F
J®F
Rights
CC BY-NC-ND
Format
PDF
Language
English
Type
Textbooks
Identifier
ISBN 978-3-03943-917-1 (Hbk); ISBN 978-3-03943-918-8 (PDF)
https://doi.org/10.3390/books978-3-03943-918-8
https://doi.org/10.3390/books978-3-03943-918-8