Molecular Psychiatry

Molecular Psychiatry

Psychiatry

The book highlights important aspects of Molecular Psychiatry, including molecular mechanisms, animal models, biomarkers, advanced methods, drugs and antidepressant response, as well as genetics and epigenetics. Molecular mechanisms are a vital part of the search for the biological basis of psychiatric disorders, providing molecular hints that can later be tested as biomarkers or targets for drug development. Animal models represent a commonly used approach to aid in this bench-to-bed translation; the examples here are social defeat stress and the Roman High-Avoidance (RHA) and the Roman Low-Avoidance (RLA) rats. For biomarkers, psychiatric disorders pose a particular challenge due to the tissue specificity of many currently investigated biomarkers; i.e., not all blood-based measures directly represent changes in the brain. The Ebook includes five articles focused on the challenges of identifying clinically and biologically relevant biomarkers for psychiatric disorders. Scientific progress typically is fostered by the development of new methods. The application of machine learning methods for the proper analysis of Big Data and induced pluripotent stem cells are examples outlined in this Ebook. Furthermore, three articles are devoted to the understanding of the mechanisms of actions of existing drugs with the ultimate goal of identifying ways to predict treatment response in patients. Finally, three articles deepen the insight into the genetics and epigenetics of psychiatric disorders.

Rein, Theo (editor)

Fries, Gabriel R. (editor)

https://directory.doabooks.org/handle/20.500.12854/68695

MDPI - Multidisciplinary Digital Publishing Institute

Publisher website
www.mdpi.com/books

2020

Sukartini

https://creativecommons.org/licenses/by/4.0/

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Eisenlohr-Moul, T.A.; Miller, A.B.; Giletta, M.; Hastings, P.D.; Rudolph, K.D.; Nock, M.K.; Prinstein, M.J.
HPA axis response and psychosocial stress as interactive predictors of suicidal ideation and behavior
in adolescent females: A multilevel diathesis-stress framework. Neuropsychopharmacol. Off. Publ. Am.
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Pdf

English

Textbooks

DOI
10.3390/books978-3-03936-121-2

ISBN
9783039361205, 9783039361212

Basel, Switzerland