Development of optical methods for real-time whole-brain functional imaging of zebrafish neuronal activity

Development of optical methods for real-time whole-brain functional imaging of zebrafish neuronal activity

Neurology

Epilepsy

Each one of us in his life has, at least once, smelled the scent of roses, read one canto of Dante’s Commedia or listened to the sound of the sea from a shell. All of this is possible thanks to the astonishing capabilities of an organ, such as the brain, that allows us to collect and organize perceptions coming from sensory organs and to produce behavioural responses accordingly. Studying an operating brain in a non-invasive way is extremely difficult in mammals, and particularly in humans. In the last decade, a small teleost fish, zebrafish (Danio rerio), has been making its way into the field of neurosciences. The brain of a larval zebrafish is made up of 'only' 100000 neurons and it’s completely transparent, making it possible to optically access it. Here, taking advantage of the best of currently available technology, we devised optical solutions to investigate the dynamics of neuronal activity throughout the entire brain of zebrafish larvae.

Lapo Turrini

https://directory.doabooks.org/handle/20.500.12854/44952

Firenze University Press

Publisher website
www.fupress.com/

2020

Sukartini

https://creativecommons.org/licenses/by/4.0/

Abraham, E., Palevitch, O., Gothilf, Y., and Zohar, Y. (2009). The zebrafish as a model system
for forebrain GnRH neuronal development. Gen Comp Endocrinol 164, 151-160.

Afrikanova, T., Serruys, A.S., Buenafe, O.E., Clinckers, R., Smolders, I., De Witte, P.A.,
Crawford, A.D., and Esguerra, C.V. (2013). Validation of the zebrafish pentylenetetrazol
seizure model: locomotor versus electrographic responses to antiepileptic drugs. PLoS One
8, e54166.

Pdf

English

Textbooks

DOI
10.36253/978-88-5518-070-2

ISBN
9788855180702

Firenze