Dublin Core
Title
Galectins in Cancer and Translational Medicine
Subject
Cancer
Description
In the post-genomic era, many efforts have been devoted to better understanding the biological information encoded by the cell “glycome” in normal and pathologic conditions. The glycan signature of human cells plays a pivotal role in regulating fundamental biological processes, which are critical for cell physiology and for cancer as well. Galectins (also worded S-type lectins) are an evolutionarily conserved family of endogenous lectins, which bind carbohydrates with high specificity. These molecules, which can be found both intracellularly and in the extracellular milieu, are functionally active in converting glycan-containing information into cell biological programs. This fashionable mechanism of signal transduction plays a relevant role in regulating several biological functions, including RNA splicing, gene transcription, cell migration and differentiation, apoptosis, immune response, and tumor growth and progression. It is not surprising, indeed, that a large number of studies on galectin–glycan interactions and galectins expression and function in human diseases have been published in the recent literature, spanning from immunology to cardiovascular medicine, from diagnostic Pathology to nuclear medicine. The aim of this Special Issue of IJMS is to collect selected contributions in the field reporting data, concepts, and new ideas, which have the potential to be translated in a clinical setting in the near future, in order to improve the diagnosis and treatment of cancer and other relevant human diseases.
Creator
Armando Bartolazzi (Ed.)
Source
https://directory.doabooks.org/handle/20.500.12854/48261
Publisher
MDPI - Multidisciplinary Digital Publishing Institute
Publisher website
www.mdpi.com/books
Date
2018
Contributor
Sukartini
Rights
https://creativecommons.org/licenses/by-nc-nd/4.0/
Relation
Pieters, R.J. Inhibition and detection of galectins. ChemBioChem 2006, 7, 721–728. [CrossRef] [PubMed]
Leffler, H.; Carlsson, S.; Hedlund, M.; Qian, Y.; Poirier, F. Introduction to galectins. Glycoconj. J. 2002,
19, 433–440. [CrossRef] [PubMed]
19, 433–440. [CrossRef] [PubMed]
Format
Pdf
Language
English
Type
Textbooks
Identifier
DOI
10.3390/books978-3-03897-409-
10.3390/books978-3-03897-409-
ISBN
9783038974093, 9783038974086
9783038974093, 9783038974086
Coverage
Basel