Microenvironment-Derived Stem Cell Plasticity

Microenvironment-Derived Stem Cell Plasticity

Stem cells--Research--Moral and ethical aspects

Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.

Marietta Herrmann

Slavko Mojsilovic

Jelena Krstic

Ivana Gadjanski

https://directory.doabooks.org/handle/20.500.12854/53417

Frontiers Media SA

2017

Dewi Puspitasari

https://creativecommons.org/licenses/by/4.0/

Acar, M., Kocherlakota, K. S., Murphy, M. M., Peyer, J. G., Oguro, H., Inra, C. N.,
et al. (2015). Deep imaging of bone marrow shows non-dividing stem cells are
mainly perisinusoidal. Nature 526, 126–130. doi: 10.1038/nature15250

English

Textbooks

DOI
10.3389/978-2-88945-344-3

Austri