The Tight Junction and Its Proteins :
More Than Just a Barrier

The Tight Junction and Its Proteins :
More Than Just a Barrier

Protein

For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.

Fromm, Michael (editor)

Krug, Susanne M. (editor)

https://directory.doabooks.org/handle/20.500.12854/69315

MDPI - Multidisciplinary Digital Publishing Institute

2020

Dewi Puspitasari

https://creativecommons.org/licenses/by/4.0/

Furuse, M.; Izumi, Y.; Oda, Y.; Higashi, T.; Iwamoto, N. Molecular organization of tricellular tight junctions.
Tissue Barriers 2014, 2, e28960. [CrossRef] [PubMed]

Pdf

English

Textbooks

DOI
10.3390/books978-3-03943-301-8

ISBN
9783039433001, 9783039433018

Basel